Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-01-18
2005-01-18
Aulakh, Charanjit S. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S134000, C546S112000, C514S299000
Reexamination Certificate
active
06844355
ABSTRACT:
The present invention provides methods for purifying, identifying and using optically active isomers of quinine and quinidine as well as compositions comprising such optically active isomers. Such optically active isomers having desired actions on cardiac sodium and potassium channel function substantially separable from undesirable effects on GI motility can be useful for more effective therapy of cardiac arrhythmias. Also disclosed are methods for assaying the levels of such isomers present in the biological fluids.
REFERENCES:
patent: 3907806 (1975-09-01), Guenter et al.
patent: 3929795 (1975-12-01), Walter et al.
patent: 0 000 302 (1979-01-01), None
Barhanin et al., (1996)Nature384(6604):78-80.
Bennet et al., (1995)Nature376:683-685.
Busch et al., (1994)Eur J. Pharmacol. 264:33-37.
Catterall, (1992)Physiol. Rev. 72(supp):S15-S48.
Chan et al., (1991)J. Chromatogr. 571:291-297.
Chen et al., (1998)Nature392:293-296.
Coplen et al., (1991)Circulation84:527.
Drabowicz et al., (1984) “Chemical Abstracts”Phosphorus Sulfur16:2676-270 (XP002165239).
Engler et al., (1985)Helv. Chim. Acta. 68:789-800.
Ficker et al., (1998)Circ. Res. 82:386-395.
Gellens et al., (1992)Proc. Natl. Acad. Sci. 89:554-558.
Gutzwiller et al., (1973) “Chemical Abstracts”Helv. Chim. Acta. 79:1494-1503 (XP002165238).
Hartmann et al. (1994)Circ. Res. 75:114-122.
Karle I.L. et al., (1981)Proc. Natl. Acad. Sci. 78:5938-5941.
Karle, J.M. (1997)Antimicrob. Agents Chemother. 41:791-794.
Kiehn et al. (1996)Circulation94:2572-2579.
Krafte et al., (1994)Europ. J. Pharma. 266:245-254.
Li et al. (1996)Circ. Res. 78:689-696.
Sanguinetti et al., (1990)J. Gen. Physiol. 96:195-215.
Sanguinetti et al., (1995)Cell81:299-307.
Sanguinetti et al., (1996)Nature384:80-83.
Spector et al., (1996)J. Gen. Phsyiol. 107:611-619.
Synders et al., (1991)Mol. Pharmacol. 41:322-330.
Trudeau et al., (1995)Science269:92-95.
Van Neuten et al. (1978)Life Sci. 28:453-458.
Wang et al., (1995)Hum. Mol. Genet. 4:1603-1607.
Willius, et al. (1942)Proc. Staff Meet. Mayo Clin. 17:294-296.
International Search Report for International Application PCT/US 00/35213.
Ranade Vasant
Somberg John C.
Academic Pharmaceuticals, Inc.
McDonnell Boehnen & Hulbert & Berghoff LLP
LandOfFree
Optically active isomers of quinine and quinidine and their... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Optically active isomers of quinine and quinidine and their..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Optically active isomers of quinine and quinidine and their... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3392851