Optically-active isomers of dideoxycarbocyclic nucleosides

Details Optically-active isomers of dideoxycarbocyclic nucleosides Optically-active isomers of dideoxycarbocyclic nucleosides

1988-12-23

1990-08-21

Rivers, Diana G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen bonded directly to ring carbon of the purine ring...

544264, 544254, 544265, 544267, 544277, C07D47318, A61K 3152

Patent

active

049507583

ABSTRACT:
Antiviral and antitumor compounds are disclosed of general formula: ##STR1## wherein Z is H, OR' or NH.sub.2, wherein R' is H, (C.sub.1 -C.sub.4)-alkyl, aryl, CHO, (C.sub.1 -C.sub.16)alkanoyl or O.dbd.P(OH).sub.2, Y is CH or N, and X is selected from the group consisting of H, N(R.sub.2), SR, OR' or halogen, wherein R is H, lower-(C.sub.1 -C.sub.4)alkyl, aryl or mixtures thereof, and the pharmaceutically-acceptable salts thereof.

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