Optically active diphosphines, preparation thereof according to

Details Optically active diphosphines, preparation thereof according to Optically active diphosphines, preparation thereof according to

1998-02-17

2000-03-14

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562480, 562553, C07C 5300

Patent

active

060374934

ABSTRACT:
The present invention relates to optically active diphosphines. It is also targeted at their preparation according to a process for the resolution of the racemic mixture of the said phosphines to optically active isomers.
The subject of the invention is new optically active bis[1-phospha-2,3-diphenyl-4,5-dimethylnorbornadiene] diphosphines and a process for resolving the racemic bis[1-phospha-2,3-diphenyl-4,5-dimethylnorbornadiene] mixture which comprises reacting it with a palladium or platinum complex as chiral auxiliary in an organic solvent, thus forming diastereoisomer complexes, and then resolving the said optically pure complexes.
The invention also relates to new optically active metal complexes comprising the said phosphines and to their use in a process for the preparation of optically active carboxylic acids and/or derivatives according to a process for the hydrogenation of .alpha.,.beta.-unsaturated carboxylic acids and/or derivatives.

REFERENCES:
patent: 5012002 (1991-04-01), Kumobayashi
patent: 5231202 (1993-07-01), Hayashi
patent: 5515944 (1996-05-01), Broger
patent: 5559267 (1996-09-01), Burk
CA:121:57572--Abstract of "The equilibrium between 1H and 2H phopholes," Laporte, Bull Soc. Fr. 139(6), pp. 843-850.
CA:117:48704--Abstract of "Mechanism of the thermal tetramerization of phospholes," Bevierre<Bull Soc. Chem Fr., 129(1)pp 1-8.
Bevierre et al, "Mechanism of the thermal tetramerization of phospholes," Bull. Soc. Chim. Fr. (BSCFAS, 00378968), vol. 129 (1), pp. 1-8, EC Polytech. Lab. Chim. Phosphore Met. Transition, Palaiseau, 91128 (FR), (1992).

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