Optically active compounding having plural chiral centers and pr

Details Optically active compounding having plural chiral centers and pr Optically active compounding having plural chiral centers and pr

1994-06-08

1995-05-02

Hollinden, Gary E.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

549274, 435195, 435198, 435243, 435822, 435911, C12P 1706

Patent

active

054118778

ABSTRACT:
An ester is caused to act on a 2-substituted-3-hydroxycarboxylic acid ester as a racemate in the presence of hydrolase under substantially anhydrous conditions to effect a transesterification resulting in the resolution.
The compound thus resolved is converted to an optically active 2,6-cis-2,5,6-substituted-1,3-dioxan-4-one and the resulting compound is recrystallized to give optically active 5,6-anti-2,5,6-substituted-1,3-dioxan-4-one and 5,6-syn-2,5,6-substituted-1,3-dioxan-4-one. Thus an optically active compound having plural chiral centers.
Further, an optically active 2,5,6-substituted-1,3-dioxan-4-one obtained by transesterification and recrystallization is reacted with an alcohol to produce an optically active 2-substituted-3-hydroxycarboxylic acid ester.

REFERENCES:
patent: 2854460 (1958-09-01), Hennes et al.
patent: 3503993 (1970-03-01), Blume
patent: 4864037 (1989-09-01), Schaffner et al.
patent: 4916074 (1990-04-01), Yoshida et al.
patent: 5128252 (1992-06-01), Miyazawa et al.
patent: 5138074 (1992-08-01), Bellis et al.
patent: 5319107 (1994-06-01), Benecke et al.
patent: 5326887 (1994-07-01), Di Cosimo et al.
Bulletin of the Chemical Society of Japan, vol. 62, No. 4, Apr. 1989, pp. 1179-1187.
Chemistry Letters, vol. 1982, pp. 1799-1802.
Tetrahedron Letters, vol. 27, 1986, pp. 3155-3156.
Agricultural and Biological Chemistry, vol. 54, No. 7, Jul. 1990, pp. 1753-1762.
Helvetica Chimca Acta, vol. 69, 1986, pp. 1147-1152.
Patent Abstracts of Japan, vol. 12, No. 283 (C-518)[31301], Aug. 3, 1988.

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