Optically active carbonates as precursors of (+)-zopiclone

Details Optically active carbonates as precursors of (+)-zopiclone Optically active carbonates as precursors of (+)-zopiclone

2005-11-29

2005-11-29

Wilson, James O. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

active

06969767

ABSTRACT:
In the present invention new compounds of formula II, in enantiomerically enriched forms, are described for the first time, where R1is chloroalkyl. The present invention also includes several new enzymatic processes for the resolution of the enantiomers of the aforementioned carbonates of formula II from the corresponding racemic mixture. The transformation of these carbonates into zopiclone enantiomerically enriched, constitutes an additional aspect of the invention.

REFERENCES:
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The Merck Index 13th ed. © 2001 MERCK & CO., INC. Whitehouse Station NJ, pp. 581 and 1426.
Gotor et al, “Enzymatic resolution of (+/−)-6-(5-chloropyridin-2-yl)-7-vinyloxy-carbonyloxy-6,7-dihydro[5H]pyrrolo[3,4-b]pyrazine 5-one. Synthesis of (+)-zopiclone” Tetrahedron: Asymmetry, vol. 8(7), pp. 995-997 (1997).
Jaeger and Eggert, “Lipases for biotechnology” Current Opinion in Biotechnology, vol. 13(4), pp. 390-397 (2002).
Sharma et al, “Production, purification, characterization, and applications of lipases” Biotechnology Advances, vol. 19, pp. 627-662 (2001).
Palomo et al, Tetrahedron Asymmetry, vol. 14, pp. 429-438 (2003).

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