Optically active carbacyclin intermediates and processes for the

Details Optically active carbacyclin intermediates and processes for the Optically active carbacyclin intermediates and processes for the

1988-12-19

1989-12-05

Lilling, Herbert J.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing heterocyclic carbon compound having only o, n, s,...

435 63, 435124, 435125, 435126, 435135, 435280, 549332, 549336, C07D31772, C12P 1702, C12P 4100, A61K 3155

Patent

active

048852465

ABSTRACT:
New intermediate, an optically active (1S,5R)-7,7-alkylenedioxy-2-alkoxycarbonylbicyclo[3.3.0]octan-3-one which is useful for the synthesis of an optically active carbacyclin. This intermediate is prepared, as a non-reduced compound, from a racemic compound, (1SR,5RS)-7,7-alkylenedioxy-2-alkoxycarbonyl-cis-bicyclo[3.3.0]octan-3-one , by treatment of the racemic compound with a microorganism. The microorganism has an ability of specifically reducing the keto group of the (1R,5S) epimer of the racemic compound.

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Chem. Abs. 10-55993(7), Oishi et al., (J63074497) 4-1988.

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