Optically active benzothiazepine compounds and process for prepa

Details Optically active benzothiazepine compounds and process for prepa Optically active benzothiazepine compounds and process for prepa

1996-12-03

1999-07-27

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540552, A01N 4346, C07D26702

Patent

active

059290684

ABSTRACT:
An optically active salt of 1,5-benzothiazepine compound of the formula (I) or (II): ##STR1## wherein each of Ring A and Ring B is a substituted or unsubstituted benzene ring, and R.sup.1 and R.sup.2 are the same or different and each is a lower alkyl group, can be prepared by resolving a racemic salt of 1,5-benzothiazepine compound of the formula (I) or (II) by means of preferential crystallization.

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J. Jacques et al., Enantiomers, Racemates and Resolutions, John Wiley & Sons (New York), 1981, pp. 223-250.
H. Kugita et al., "Synthesis of 1,5-Benzothiazepine Derivatives. III," Chemical and Pharmaceutical Bulletin, vol. 19, No. 3 (1971), pp. 595-602.
Schwartz et. al., "Enantioselective Synthesis . . . Diltiazem Group", J. Org. Chem., vol. 57 (Jan. 31, 1992), No. 3, pp. 851-856.
Kojie-Prodie et. al., "Absolute Conformation and Configuration of . . . ", Helv. Chim. Acta, vol. 67 (1984), Fasc. 3, pp. 916-926.

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