Optically active 4-morpholino-2-(1-naphthylmethyl)-4-oxobutyric

Details Optically active 4-morpholino-2-(1-naphthylmethyl)-4-oxobutyric Optically active 4-morpholino-2-(1-naphthylmethyl)-4-oxobutyric

1991-07-02

1992-04-21

Ramsuer, Robert W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C07D295192

Patent

active

051069709

ABSTRACT:
Optically active 4-morpholino-2-(1-naphthylmethyl)-4-oxobutyric acid 2'-hydroxy-1,1'-binaphthalen-2-yl represented by formula (I): ##STR1## wherein * indicates an asymmetric carbon atom, which is prepared by reacting 4-morpholino-4-oxobutyric acid 2'-hydroxy-1,1'-binaphthalen-2-yl represented by formula (II): ##STR2## with a 1-halomethylnaphthalene in the presence of a base. The compound (I) is a useful intermediate for preparing pharmaceuticals such as a renin inhibitors.

REFERENCES:
patent: 4656269 (1987-04-01), Iizuka et al.

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