Organic compounds -- part of the class 532-570 series – Organic compounds – Four or more ring nitrogens in the bicyclo ring system
Patent
1991-07-02
1992-04-21
Ramsuer, Robert W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Four or more ring nitrogens in the bicyclo ring system
C07D295192
Patent
active
051069709
ABSTRACT:
Optically active 4-morpholino-2-(1-naphthylmethyl)-4-oxobutyric acid 2'-hydroxy-1,1'-binaphthalen-2-yl represented by formula (I): ##STR1## wherein * indicates an asymmetric carbon atom, which is prepared by reacting 4-morpholino-4-oxobutyric acid 2'-hydroxy-1,1'-binaphthalen-2-yl represented by formula (II): ##STR2## with a 1-halomethylnaphthalene in the presence of a base. The compound (I) is a useful intermediate for preparing pharmaceuticals such as a renin inhibitors.
REFERENCES:
patent: 4656269 (1987-04-01), Iizuka et al.
Fuji Kaoru
Node Manabu
Tanaka Fujie
Ramsuer Robert W.
Takasago International Corporation
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