Optically active 3-demethylmevalonic acid derivatives, and inter

Details Optically active 3-demethylmevalonic acid derivatives, and inter Optically active 3-demethylmevalonic acid derivatives, and inter

1988-12-06

1990-11-13

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544300, 544301, 544310, 544311, 544313, 544314, 544316, 544317, 546256, 546257, 546258, 546261, 546262, 546263, 546267, 546268, 546281, 546283, 546284, 546296, 546298, 546299, 546301, 546302, 546315, 546318, 546321, 546322, 546326, 546327, 546341, 546342, 556413, 556418, 556437, 556438, 560 60, 549291, 549372, C07D23902, C07D21379, C07D31316, C07F 704, C07C 6976

Patent

active

049703137

ABSTRACT:
A process for the preparation of optically active 3-de-methylmevalonic acid derivatives, and intermediates A process for the preparation of optically active 3-de-methylmevalonic acid derivatives of the formula I ##STR1## (3,5-dihydroxy carboxylic acid derivatives) or of the formula II ##STR2## (.beta.-hydroxy lactones) in which R, R.sup.1 and Y have the indicated meanings, is described. The invention furthermore relates to aldehydes of the formula XII ##STR3## in which M represents the indicated protective groups. The 3-demethylmevalonic acid derivatives of this invention are useful for lowering cholesterol levels of a host.

REFERENCES:
Lynch et al., Tetrahedron Letters, vol. 28, 1987, pp. 1385-1388.
Rosen et al., Tetrahedron Letters, vol. 42, 1986, pp. 4909-4951.
Prugh et al., Journal of Organic Chemistry, vol. 51, 1986, pp. 648-657.
Guindon et al., Tetrahedron Letters, vol. 26, 1985, pp. 1185-1188.
Sletzinger et al., Tetrahedron Letters, vol. 25, 1985, 2951-2954.
Prugh et al., Tetrahedron Letters, vol. 23, 1982, pp. 281-284.
Yang et al., Tetrahedron Letters, vol. 23, 1982, pp. 4305-4308.

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