Optically active 3-(1-(carbamoyl))alkyl-2-oxo-pyrrolidines and o

Details Optically active 3-(1-(carbamoyl))alkyl-2-oxo-pyrrolidines and o Optically active 3-(1-(carbamoyl))alkyl-2-oxo-pyrrolidines and o

1999-05-10

2000-10-31

McKane, Joseph K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20709

Patent

active

061405108

ABSTRACT:
This invention relates to processes for the synthesis of various optically active amino pyrrolidinyl stereoisomers, or enantiomers, that may be attached to quinolonecarboxylic acids or naphthyridones. Processes and essential intermediates are disclosed and claimed for the synthesis of compounds represented by the structure shown in figure BG.sub.4-1, below. ##STR1## where R.sup.50, R.sup.6 and R.sup.9 are defined independently and are H, --(C.sub.1 -C.sub.8)alkyl, --(C.sub.3 -C.sub.8)cycloalkyl, --(C.sub.1 -C.sub.8)alkyl-(C.sub.3 -C.sub.8)cycloalkyl, --(C.sub.6 -C.sub.12 aryl), --(C.sub.1 -C.sub.8)alkyl-(C.sub.6 -C.sub.12 aryl), or the aryl or alkyl is substituted with one to three of the following groups, (C.sub.6 -C.sub.12 aryl), (C.sub.1 -C.sub.3)alkyl, (C.sub.1 -C.sub.3) alkoxy, halogen, trifluoromethyl;

REFERENCES:
patent: 5157128 (1992-10-01), Hagen et al.
patent: 5281612 (1994-01-01), Domagala et al.
Archelas, A. et at., Tetrahedron Letters, 29, 50, pp. 6611-6614 (1988).
Davies, S., "Chiral Lithium Organoamide Technology Available," from Oxford Asymmetry Limited, Oxfordshire, UK (Lithium Link), 1991.
Davies, S., et al., Tetrahedron: Asymmetry, vol. 2, No. 3, pp. 183-186 (1991).
Davis, F.A., et al., Journal of the American Chemical Society, vol. 109, No. 11, pp. 3370-3377 (1987).
Domagala, John M., et al. Journ. of Medicinal Chem., 36, 7, pp 871-882 (1993).
Estermann, V., et al., Helvetica Chimica Acta, vol. 71, pp. 1824-1839 (1988).
Furukawa, M., et al., Chemical Pharmaceutical Bulletin, vol. 27(9), pp. 2223-2226 at 6 (1979).
Guanti, Giuseppe, et al., in Tetrahedron Letters 28 (37), pp. 4335-4338 (1987).
Hagen, Susan E., et al., Journ. Of Medicinal Chem., 37, 6, pp. 733-738 (1994).
Liebeskind, Lanny S., et al., Journ. of the American Chem. Soc., 108, 29, pp. 6328-6343 (1986).
Orsini, F., et al., Synthetic Communications, vol. 12, No. 14, pp. 1147-1154 (1982).
Plummer, Janet S., et al., Tetrahedron Letters, 34, 47, pp. 7529-7532 (1993).
Schroder, M.C., et al., Journal of Heterocyclic Chemistry, vol. 29, No. 6, pp. 1481-1498 (1992).
Seebach and Esterman, Tetrahedron Letters, 28, 27, pp. 3103-3106 (1987).
Database WPI Week 9119, Derwent Publication Ltd. AN 91-136059 and JP A 3 072 476-Abstract, 1991.
Helvetica Chimica Acta, vol. 66, Fasc. 2, Nr. 38, p. 461 (1983).

Affiliated with

Also associated with

Rating

Optically active 3-(1-(carbamoyl))alkyl-2-oxo-pyrrolidines and o does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Optically active 3-(1-(carbamoyl))alkyl-2-oxo-pyrrolidines and o, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Optically active 3-(1-(carbamoyl))alkyl-2-oxo-pyrrolidines and o will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2053716