Optically active 3-(1-(alkylamino))alkyl pyrrolidines

Details Optically active 3-(1-(alkylamino))alkyl pyrrolidines Optically active 3-(1-(alkylamino))alkyl pyrrolidines

1997-07-24

1999-10-05

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548579, 548550, C07D20709, C07D20712

Patent

active

059626976

ABSTRACT:
This invention relates to processes for the synthesis of various optically active amino pyrrolidinyl stereoisomers, or enantiomers, that may be attached to quinolonecarboxylic acids or naphthyridones. Processes and essential intermediates are disclosed and claimed for the synthesis of compounds represented by the structure shown in figure BG.sub.4-1, below. ##STR1## where R.sup.50, R.sup.6 and R.sup.9 are defined independently and are H, --(C.sub.1 -C.sub.8)alkyl, --(C.sub.3 -C.sub.8)cycloalkyl, --(C.sub.1 -C.sub.8)alkyl-(C.sub.3 -C.sub.8)cycloalkyl, --(C.sub.6 -C.sub.12 aryl), --(C.sub.1 -C.sub.8) alkyl-(C.sub.6 -C.sub.12 aryl), or the aryl or alkyl is substituted with one to three of the following groups, (C.sub.6 -C.sub.12 aryl), (C.sub.1 -C.sub.3)alkyl, (C.sub.1 -C.sub.3) alkoxy, halogen, trifluoromethyl;

REFERENCES:
Domagala, John M. et al., Quinolone Antibacterials Containing the New 871-872, Apr. 1993.
Schroeder, Mel. C. et al., Synthesis of the Four Stereoisomers of Several 3-(1-Aminoethyl)pyrrolidines, Oct. 1992.

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