Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof
Reexamination Certificate
2007-10-16
2007-10-16
Tsang, Cecilia (Department: 1609)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carboxylic acids and salts thereof
C562S443000, C560S115000, C560S020000
Reexamination Certificate
active
10553394
ABSTRACT:
The present invention provides a process for producing an optically active 2-allylcarboxylic acid derivative, which is useful as a pharmaceutical intermediate, from readily available and inexpensive starting materials by the process which can be practiced on a commercial scale in a simple and easy manner, and certain 2-allylcarboxamide derivatives, which are novel and important intermediates in that process.An N-allylcarboxamide derivative undergoes rearrangement reaction diastereoselectively in the presence of a base to give a 2-allylcarboxamide derivative, the resulting derivative is subjected to a carbamation reaction and solvolysis to give an optically active 2-allylcarboxylic acid ester, and then the ester obtained is stereoselectively hydrolyzed using an enzyme to produce 2-allylcarboxylic acid having a high optical purity. In addition, the present invention provides a 2-allylcarboxamide derivative compound which is a novel intermediate in the process of the present invention.
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Amano Susumu
Ito Noriyuki
Kizaki Noriyuki
Mitsuda Masaru
Okuro Kazumi
Kaneka Corporation
Loewe Sun Jae Y
Ono Pharmaceutical Co. Ltd.
Sughrue & Mion, PLLC
Tsang Cecilia
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