Optically active 1-phenyl-2-substituted propane derivatives and

Details Optically active 1-phenyl-2-substituted propane derivatives and Optically active 1-phenyl-2-substituted propane derivatives and

1997-06-27

1999-05-11

Burn, Brian M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

564399, C07C209/22

Patent

active

059029005

ABSTRACT:
An (S)-1-phenyl-2-substituted propane derivative shown by the following formula (I) ##STR1## wherein R.sup.1 and R.sup.2 represent a lower alkyl group, etc., or R.sup.1 and R.sup.2 may form together an alkylene group, etc.; R.sup.3, R.sup.4 and R.sup.5 represent a hydrogen atom, etc.; and X represents a hydroxyl group which may be protected with a protective group, or a halogen atom etc., can readily be produced (i) by permitting a microorganism belonging to the genus Torulaspora, the genus Candida, the genus Pichia or the like to act on a phenylacetone derivative and asymmetrically reducing the compound, or (ii) by sterically inverting an derivative having a high optical purity can easily be obtained from the compound of the formula (I). The ethanol derivative is useful as an anti-obesity agent and the like.

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patent: 5385833 (1995-01-01), Bradshaw et al.
Bloom, J., et al., -2,2-dicarboxylate (CL 316,248). A Patent .beta.-Adrenergic Agonist Virtually Specific for .beta..sub.3 Receptors, A Promising Antidiabetic and Antiobesity Agency; J. Med. Chem., vol. 35, No. 16, pp. 3081-3084 (1992).
Reiner Luckenback, Beilsteins Handbook of Organic Chemistry, 1981, pp. 7403-7404.
Conserva et al., Photochemistry, 29(1), 257-260 (1990).
Marques et al., Photochemistry, 30(1), 360-361 (1992).

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