Optically-active 1-aryloxy-2-propanol intermediates of (S)-absol

Details Optically-active 1-aryloxy-2-propanol intermediates of (S)-absol Optically-active 1-aryloxy-2-propanol intermediates of (S)-absol

1977-12-20

1980-01-08

Demers, Arthur P.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

568583, 568584, 568586, 568587, 568636, 568637, 568638, 568643, 568644, 568645, 568646, 568648, 568649, 568650, 568654, C07C 4320

Patent

active

041829115

ABSTRACT:
Novel optically-active (S)- 1-aryloxy-2,3-epoxy-propane derivatives, a process for their manufacture, various intermediates used in the preparation thereof, and a process for using them for the manufacture of optically-active (S)-1-aryloxy-3-amino-2-propanol derivatives useful as .beta.-adrenergic blocking agents.

REFERENCES:
patent: 2738351 (1956-03-01), Dickison et al.
patent: 3494939 (1970-02-01), Smith
patent: 3686320 (1972-08-01), Fitzmaurice et al.
Sh. Mamedov et al., "Ethers of glycols and their derivatives" in Chem. Abs., vol. 60, May. 1964, 13172g.
Danilewicz et al., J. Med. Chem., 1973, vol. 16, No. 2, pp. 168, 169.
Balfe et al., "The Dependence of Optical Rotary Power" in J. Chem. Soc. 1950, pp. 1861-1866.

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