Optically active 1,4-dihydropyridine compounds as bradykinin ant

Details Optically active 1,4-dihydropyridine compounds as bradykinin ant Optically active 1,4-dihydropyridine compounds as bradykinin ant

1998-08-13

2000-12-05

Fan, Jane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514255, 514256, 514305, 514318, 544362, 544365, 544364, 544333, 546133, 546194, C07D40106, A61K 31497

Patent

active

061567523

ABSTRACT:
This invention provides a compound of the formula (I): ##STR1## and its pharmaceutically acceptable salts, wherein A.sup.1 and A.sup.2 are each halo; R.sup.1 and R.sup.2 are independently C.sub.1-4 alkyl; R.sup.3 is substituted or unsubstituted, phenyl or naphthyl; Y is heterocyclic group selected from C.sub.5-10 azacycloalkyl, C.sub.6-10 diazacycloalkyl, C.sub.7-10 azabicycloalkyl and the like; and R.sup.4 is selected from (a) substituted or unsubstituted C.sub.1-8 alkyll; (b) substituted or unsubstituted amino; (c) substituted or unsubstituted C.sub.2-6 alkanoyl; (d) substituted or unsubstituted C.sub.3-8 cycloalkyl or C.sub.7-14 bicycloalkyl; (e) substituted or unsubstituted C.sub.5-10 azacycloalkyl or C.sub.6-10 diazacycloalkyl, and (f) substituted or unsubstituted C.sub.7-14 mono- or di-azabicycloalkyl. These compounds are useful for the treatment of medical conditions caused by bradykinin such as inflammation, cardiovascular disease, pain, etc. This invention also provides a pharmaceutical composition comprising the above compound, and intermediates of the above compounds.

REFERENCES:
patent: 4510310 (1985-04-01), Wehinger et al.
patent: 4578467 (1986-03-01), Bonacchi et al.
patent: 4786641 (1988-11-01), Goldmann et al.

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