Optically active 1,4-benzodiazepines intermediates

Details Optically active 1,4-benzodiazepines intermediates Optically active 1,4-benzodiazepines intermediates

1976-07-29

1978-05-02

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

26032614R, C07C12506, C07D20920

Patent

active

040876144

ABSTRACT:
Optically active intermediates of the formula: ##STR1## in the S optical configuration wherein R.sub.1 is selected from the group consisting of hydrogen, halogen, nitro and trifluoromethyl, R.sub.2 is selected from the group consisting of hydrogen and C.sub.1-4 lower alkyl, and R.sub.3 is selected from the group consisting of C.sub.1-4 lower alkyl, hydroxy C.sub.1-4 lower alkyl, phenyl, hydroxyphenyl, benzyl, hydroxybenzyl, or 3'-methyleneindolyl, and A is a protective group, and their preparation is described. These compounds are useful in the preparation of corresponding optically active 1,4-benzodiazepines.

REFERENCES:
patent: 3371085 (1968-02-01), Reeder et al.
patent: 3927010 (1975-12-01), Hellerbach et al.
patent: 3998811 (1976-12-01), Kajfez et al.
Sternbach et al., J. Org. Chem., vol. 27, (1962), pp. 3788-3796.

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