Optically active 1,4-benzodiazepines and process for the prepara

Details Optically active 1,4-benzodiazepines and process for the prepara Optically active 1,4-benzodiazepines and process for the prepara

1974-07-30

1976-12-21

Jiles, Henry R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260562N, 424244, 424274, 26032614R, C07D24324

Patent

active

039988112

ABSTRACT:
Optically active compounds having the formula ##STR1## having an asymmetric carbon atom in position 3 having the S configuration and wherein R.sub.1 is selected from the class consisting of hydrogen, halogen, nitro, and trifluoromethyl groups, R.sub.2 is selected from the group consisting of hydrogen and C.sub.1-4 lower alkyl groups and R.sub.3 is selected from the group consisting of C.sub.1-4 lower alkyl, hydroxy C.sub.1-4 lower alkyl, phenyl, hydroxy phenyl, benzyl, hydroxy benzyl, and 3'-methyleneindolyl groups.
They are obtained by reaction of a compound having the formula ##STR2## with a compound of the formula wherein A is a protective group.
The compounds of formula I have sedative and tranquilizing properties.

REFERENCES:
patent: 3371085 (1968-02-01), Reeder et al.
Sternbach et al. "J. Org. Chem." vol. 27, pp. 3788-3796 (1962).

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