Optical waveguide bio-sensing device

Details Optical waveguide bio-sensing device Optical waveguide bio-sensing device

2006-10-02

2009-12-22

Le, Uyen-Chau N (Department: 2874)

Optical waveguides

Optical waveguide sensor

C385S037000

Reexamination Certificate

active

07636502

ABSTRACT:
An optical waveguide bio-sensing device, comprising: a monochromatic light source, a beam splitter, a grating chip with a sub-wavelength grating structure and a sensor. Moreover, in order to enhance the sensitivity of the system using the optical waveguide bio-sensing device, a light concentrating element or a quarter waveplate (¼λ) is arranged in the optical path during detection. When the grating chip is not coated with a layer of biochemical substance corresponding to a monochrome light emitted from the monochromatic light source, a reflected light of a specific narrow wavelength is reflected by a specific angle as a surface plasmon resonant effect caused by waveguide coupling is excited by the incidence of the monochrome light to the grating chip through the beam splitter; otherwise, there will be little or no reflection. Accordingly, the optical waveguide bio-sensing device can detect bio-molecular interactions, reaction rate and/or molecular dynamics without any labeling in real time. Optical systems using the present invention are simplified and capable of being portable. Thus a high sensitivity detection technique is achieved.

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patent: 7027163 (2006-04-01), Angeley
patent: 2003/0068657 (2003-04-01), Lin et al.
patent: 2005/0068543 (2005-03-01), Angeley
patent: 2006/0039647 (2006-02-01), Ling et al.
patent: 2007/0122077 (2007-05-01), Bellman et al.

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