Optical system and method for non-invasive imaging of biological

Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation

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600323, 600328, 600431, 600476, A61B 500

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058533702

ABSTRACT:
An optical system for in vivo, non-invasive imaging of tissue change including an optical module, a spectrophotometer, and a processor. The optical module includes an array of input ports and detection ports located in a selected geometrical pattern to provide a multiplicity of arrayed source-detector pairs engaged directly with the subject. The spectrophotometer includes at least one light source constructed to introduce electromagnetic radiation of visible or infra-red wavelength into the examined tissue successively at the input ports, wherein the wavelength is sensitive to a constituent of the imaged tissue, and at least one detector constructed to detect, at the detection ports, radiation of the selected wavelength that has migrated in the tissue from respective input ports. The processor receives signals of the detected radiation from the detector means, and is constructed and arranged to create a defined spatial image of the tissue by effectively producing from signals from the multiplicity of photon migration paths in the tissue, a succession of data sets representing, from a selected view, a succession of spatial images of the tissue being stimulated and the tissue not being stimulated, and an image data set related to differences between data of the successive data sets of the stimulated and non-stimulated tissue.

REFERENCES:
patent: 3638640 (1972-02-01), Shaw
patent: 4281645 (1981-08-01), Jobsis
patent: 4515165 (1985-05-01), Carroll
patent: 4937526 (1990-06-01), Ehman et al.
patent: 4940453 (1990-07-01), Cadwell
patent: 5088493 (1992-02-01), Giannini et al.
patent: 5090415 (1992-02-01), Yamashita et al.
patent: 5143081 (1992-09-01), Young et al.
patent: 5158090 (1992-10-01), Waldman et al.
patent: 5218962 (1993-06-01), Mannheimer et al.
patent: 5287276 (1994-02-01), Crawford et al.
patent: 5402778 (1995-04-01), Chance
patent: 5431170 (1995-07-01), Mathews
PCT International Search Report, Int'l Appln. No. PCT/US97/16309, mailed Feb. 10, 1998, 9 pp.
Apicella et al., "Fast multi-modality image matching," SPIE, vol. 1092, pp. 252-263, 1989.
Arridge, "The Forward and Inverse Problems in Time Resolved Infra-Red Imaging," Medical Optical Tomography: Functional Imaging and Monitoring, SPIE Optical Engineering Press, vol. IS11, pp. 35-64, 1993.
Benaron et al., "A Medical Perspective at the Threshold of Clinical Optical Tomography," Medical Optical Tomography: Functional Imaging and Monitoring, SPIE Optical Engineering Press, vol. IS11, pp. 3-9, 1993.
Colak et al., "Optical BackProjection Tomography in Heterogeneous Diffusive Media," Advances in Optical Imaging and Photon Migration, TOPS (Trends in Optics and Photonics Series), vol. 2, pp. 282-289, Mar., 1996.
Feng et al., "Analytical perturbation theory of photon migration in the prescence of a single absorbing or scattering defect sphere," SPIE, vol. 2389, pp. 54-63, 1995.
Hajnal et al., "Artifacts Due to Stimulus Correlated Motion in Functional Imaging of the Brain," MRM, pp. 283-291, 1994.
Hoshi et al., "Detection of dynamic changes in cerebral oxygenation coupled to neuronal function during mental work in man," Neuroscience Letters, vol. 150, pp. 5-8, 1993.
Maki et al., "Spatial and temporal analysis of human motor activity using noninvasive NIR topography," Med. Phys., vol. 22, No. 12, pp. 1997-2005, 1995.
Matcher et al., "Absolute quantification methods in tissue near infrared spectroscopy," SPIE, vol. 2389, pp. 486-495, 1995.
Nioka et al., "Optical Imaging of Breast Tumors with various methods," Oxygen Transport to Tissue, vol. XVIII, pp. 227-232, 1997.
Oda et al., "Non-Invasive Hemoglobin Oxygenation Monitor and Computerized Tomography of NIR Spectrophotometry," SPIE, vol. 1431, p. 204, 1991.
Ogawa et al., "The Sensitivity of Magnetic Resonance Image Signals of a Rat Brain to Changes in the Cerebral Venous Blood Oxygenation," Magnetic Resonance in Medicine, vol. 29, pp. 205-210, 1993.
Pelizzari et al., "Accurate Three-Dimensional Registration of CT, PET, and/or MR Images of the Brain," J. Computer Assisted Tomography, vol. 13, No. 1, pp. 20-26, 1989.
Polishchuk et al., "Non-Euclidean diffusion and `Fermat` photons in turbid media," SPIE, vol. 2389, pp. 6-9, 1995.
Sevick et al., "The physical basis of biomedical optical imaging using time-dependent measurements of photon migration in the frequency-domain," Medical Optical Tomography: Functional Imaging and Monitoring, SPIE Optical Engineering Press, vol. IS11, pp. 485-512, 1993.
Sevick et al., "Quantitation of Time-and Frequency-Resolved Optical Spectra for the Determination of Tissue Oxygenation," Analytical Biochem., 195:330-351, 1991.
Singer et al., "Image Reconstruction of the Interior of Bodies That Diffuse Radiation," Science, vol. 228, pp. 990-993, 1990.
Woods et al., "Rapid Automated Algorithm for Aligning and Reslicing PET Images," J. Computer Assisted Tomography, vol. 16, No. 4, pp. 620-633, 1992.

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