Optical solid-phase biosensor based on polyionic layers labelled

Details Optical solid-phase biosensor based on polyionic layers labelled Optical solid-phase biosensor based on polyionic layers labelled

1995-10-24

1998-01-27

Marschel, Ardin H.

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

Means for analyzing liquid or solid sample

422 50, 422 55, 422 56, 422 57, 422 69, 422 8205, 422 8206, 422 8207, 422 8208, 435 6, 435 71, 435 792, 435174, 435180, 435181, 4352831, 4352871, 4352872, 4352873, 4352877, 4352878, 4352879, 4352887, 4352901, 4352921, 435808, 436501, 436518, 436524, 436527, 436528, 436531, 436532, 436535, 436 63, 436164, 436169, 436170, 935 76, 935 77, 935 78, 935 85, 935 86, C12M 140, C12Q 168, C07H 2102, C07H 2104

Patent

active

057119155

ABSTRACT:
The present invention relates to an optical solid-phase biosensor for the detection of molecules which can be labelled with a fluorescent dye for the identification of substances in solution, for which there exists a biomolecule (receptor) which specifically recognises these and is chemically bonded to the uppermost layer of one or more layers of polyions on the surface of the sensor, by measurement of the Forster transfer between another dye molecule which is bonded in one of the uppermost layers of the sensor, and the said dye molecule.

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Pachmann, et al., "Poly-L-lysine as a coating agent . . . ", Biomedicine, vol. 33, No. 7, 1980, pp. 210-211.
Japanese Abstract Publication No. JP 1126557 (1989).
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E.F. Ulman, P.L. Khanna, Methods in Enzymology, 74 (1981), pp. 28-60.
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S.M. Barnard, D.R. Walt, Science 251, 927-929.
R.G. Sommer et al., Clin. Chem. 36, pp. 201-206 (1990).
Patel et al. (1983) Analytical Biochemistry, vol. 129, pp. 162-169.

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