Optical sensor of plasma constituents

Details Optical sensor of plasma constituents Optical sensor of plasma constituents

1980-04-28

1982-08-17

Recla, Henry J.

Surgery

Truss

Pad

A61B 500

Patent

active

043444385

ABSTRACT:
A system for monitoring low molecular weight compounds in blood plasma in the body by optical means includes a chamber which can be inserted into the blood stream and which contains specific receptor sites for the plasma constituent to be analyzed. The chamber interior is isolated from the blood by a dialysis membrane which permits the plasma constituents to diffuse into the chamber. A competing ligand for the receptor sites is placed within the chamber, but due to its relatively large molecular size the competing ligand cannot escape through the dialysis membrane into the bloodstream. Light emitted or absorbed by the competing ligand gives a measure of the concentration of the selected low molecular weight compounds in the blood.

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patent: 3992631 (1976-11-01), Harte
Ransom, J. P., Practical Competitive Binding Assay Methods, C. V. Mosby Co., St. Louis., 1976, pp. 45-47.
Schultz, J. S. et al., Biotech. & Bioengng. Symp., No. 9, 65-71, (1979).

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