Optical sensor for enzyme and enzyme substrates

Details Optical sensor for enzyme and enzyme substrates Optical sensor for enzyme and enzyme substrates

1997-01-06

1999-11-30

Redding, David A.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 14, 4352879, 4352887, 422 8211, G01N 3353

Patent

active

059940913

ABSTRACT:
Sensor devices for use in assaying for a substance selected from (i) enzymes capable of producing a change in their environment as a result of catalytic reaction with a substrate and (ii) substrates for such enzymes is described, the devices comprising an optical waveguide having immobilized directly or indirectly on a discrete region ("the measurement region") of one longitudinal surface thereof a species whose optical properties change as a result of the aforementioned change in its environment together with the member of an enzyme substrate/enzyme pair complementary to the substance under assay. Methods of assay using such devices are also described.

REFERENCES:
patent: Re33064 (1989-09-01), Carter
patent: 4880752 (1989-11-01), Keck
patent: 4889407 (1989-12-01), Markle et al.
patent: 4978503 (1990-12-01), Shanks
patent: 5192802 (1993-03-01), Attridge
patent: 5300779 (1994-04-01), Hillman
Patent Abstracts of Japan, vol. 14, No. 21 (P-990) Jan. 17, 1990 & JP A 12 63 537 (NOK Corp.) Oct. 20, 1989.

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