Optical resolution of threo-2-hydroxy-3-(2-aminophenylthio)-3-(4

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acid esters

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

560 17, 562401, 562402, 562431, C07C31928, C07B 5700

Patent

active

053027418

ABSTRACT:
D(+)-threo-2-hydroxy-3-(2-aminophenylthio)-3-(4-methoxyphenyl)propionic acid, an important intermediate in the synthesis of diltiazem hydrochloride, is obtained in better yields and high optical purity by a novel resolution process comprising the reaction of 2 moles of the (.+-.) racemic acid with 1 mole of quinine and 1 mole of a base in a suitable polar solvent system to form a salt of the D(+) acid and quinine which precipitates; separating said salt and decomposing it with a strong base.

REFERENCES:
patent: 4552695 (1985-11-01), Igarashi et al.
patent: 5008411 (1991-04-01), Coffen et al.
patent: 5097059 (1992-03-01), Giordano et al.
patent: 5183922 (1993-02-01), Rizzi et al.
Jacques, Jean et al., "Enantiomers, Racemates and Resolutions", 1981, John Wiley & Sons, New York, Brisbane, Chickester, Toranto, pp. 307-312.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Optical resolution of threo-2-hydroxy-3-(2-aminophenylthio)-3-(4 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Optical resolution of threo-2-hydroxy-3-(2-aminophenylthio)-3-(4, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Optical resolution of threo-2-hydroxy-3-(2-aminophenylthio)-3-(4 will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2099824

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.