Optical resolution of racemic femoxetine

Details Optical resolution of racemic femoxetine Optical resolution of racemic femoxetine

1984-02-29

1986-02-18

Milestone, Norma S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D21122

Patent

active

045714240

ABSTRACT:
A process for the optical resolution of the enantiomers of trans-3-[(4-methoxyphenoxy)-methyl]-1-methyl-4-phenylpiperidine, which involves reaction with an enantiomer of mandelic acid to form a mixture of diastereomeric compounds, precipitating one of the diastereoisomers, and converting it to the desirable free (+)-trans isomer, as well as the key diastereomeric isomer intermediate, is disclosed.

REFERENCES:
J. C. Craig et al., Jour. Org. Chem., vol. 36 (23) (1971), pp. 3648-3649.

Affiliated with

Also associated with

Rating

Optical resolution of racemic femoxetine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Optical resolution of racemic femoxetine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Optical resolution of racemic femoxetine will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1551183