Optical resolution of racemic alcohols

Details Optical resolution of racemic alcohols Optical resolution of racemic alcohols

1988-12-21

1991-02-26

Rosen, Sam

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435155, 435135, 435136, C12P 702, C12P 762

Patent

active

049961586

ABSTRACT:
A racemic alcohol is subjected to the optical resolution by irreversibly esterifying one of the two antipodes of the racemic alcohol with an acid anhydride or enol ester of a carboxylic acid in a organic solvent in the presence of a hydrolase. This optical resolution uses a non-aqueous organic solvent in which the hydrolase is insoluble and involves an irreversible esterification, thus permitting an efficient optical resolution and improving recovery and re-usability of the hydrolase.

REFERENCES:
Grant & Hackh's Chemical Dictionary, 1987, pp. 40 and 587.
Degueil-Castaing et al, Enzymatic Reactions in Organic Synthesis, 1987, pp. 953-954.
Chen, Quantitative Analyses of Biochemical Kinetic Resolution, 1987, pp. 2812-2817.
Cambou et al-J. Am. Chem. Soc., vol. 106 (1984), pp. 2687-2692.
Kirchner et al-J. Am. Chem. Soc., vol. 107 (1985), pp. 7072 to 7076.

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