Optical resolution of DL-3-acylthio-2-methylpropanoic acid

Details Optical resolution of DL-3-acylthio-2-methylpropanoic acid Optical resolution of DL-3-acylthio-2-methylpropanoic acid

1988-01-15

1991-03-19

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Esters having the thiocarboxylate group, -cx-, wherein the...

558254, 562401, 562426, 564385, 564386, 564389, 564302, 564304, C07C32732

Patent

active

050012517

ABSTRACT:
An optically active amine compound and a method for preparing same are provided which compound has the structure ##STR1## in the form of its R-(+) enantiomer or S-(-) enantiomer, wherein R and R.sup.1 are independently H, lower alkyl or halogen, R.sup.2 is H or lower alkyl and R.sup.3 is lower alkyl, the optically active amine is useful in the optical resolution of DL-3-acylthio-2-methylpropanoic acid wherein acyl is acetyl or benzoyl. The optically active D-(+)-3-acylthio-2-methylpropanoic acids are used as intermediated for preparing antihypertensive agents, such as captopril.

REFERENCES:
patent: 4224457 (1980-09-01), Iwao et al.
patent: 4297282 (1981-10-01), Ohashi et al.
patent: 4325886 (1982-04-01), Ohashi et al.
patent: 4346045 (1982-08-01), DeHeij
patent: 4585595 (1986-04-01), Houbiers

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