Optical resolution of DL-3-acetylthio-2-methylpropionic acid usi

Details Optical resolution of DL-3-acetylthio-2-methylpropionic acid usi Optical resolution of DL-3-acetylthio-2-methylpropionic acid usi

1993-10-19

1994-11-22

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Esters having the thiocarboxylate group, -cx-, wherein the...

564303, C07C30706, C07B 5700

Patent

active

053670914

ABSTRACT:
This invention refers to a new process for the preparation of D-(-)-3-acetylthio-2-methylpropionic acid, an important intermediate in the synthesis of the antihypertensive Captopril, consisting of the resolution of the racemic mixture of said acid through formation of the mixture of the diastereomeric salts thereof, in an appropriate solvent, with the low molecular weight L-(+)-2-aminobutanol as a base, selective crystallization of the diastereomeric salt of D-(-)-3-acetylthio-2-methylpropionic acid with L-(+)-2-aminobutanol and release of the D-(-)-3-acetylthio-2-methylpropionic acid through displacement of the base with a stronger acid.

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