Optical resolution of chlorohydrin with microorganism

Details Optical resolution of chlorohydrin with microorganism Optical resolution of chlorohydrin with microorganism

1996-05-21

1998-07-07

Beisner, William H.

Chemistry: molecular biology and microbiology

Process of utilizing an enzyme or micro-organism to destroy...

Resolution of optical isomers or purification of organic...

435132, 435155, 435158, C12P 4100

Patent

active

057767661

ABSTRACT:
A novel method for preparing optically active chlorohydrin compound and optically active 1,2-diol compound and/or optically active 3-hydroxy-.gamma.-butyrolactone which are useful as intermediates for preparing medicaments, agricultural chemicals, physiologically active substances and ferroelectric liquid crystals, which comprises treating a racemic chlorohydrin compound having the formula: ##STR1## wherein R.sup.1 is H or lower alkyl group; and R.sup.2 is substituted or unsubstituted lower alkyl group when R.sup.1 is H; or R.sup.2 is H when R.sup.1 is lower alkyl group with a microorganism, whereby selectively degrading only one of optical isomers thereof, and recovering the remaining an other optically active chlorohydrin and isolating optically active 1,2-diol compound and/or optically active 3-hydroxy-.gamma.-butyrolactone converted by the reaction.

REFERENCES:
patent: 5155043 (1992-10-01), Murakami et al.
Agric. Biol. Chem., vol. 50, No. 2, pp. 375-380, Japan, 1986.

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