Optical resolution method of a nicotine derivate

Details Optical resolution method of a nicotine derivate Optical resolution method of a nicotine derivate

1993-12-09

1995-05-30

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546282, C07D40100

Patent

active

054202868

ABSTRACT:
Disclosed is a method of obtaining (S)-(-)-3-(1-methyl-2-pyrrolidinyl)-2-pyridone (2) and (R)-(+)-3-(1-methyl-2-pyrrolidinyl)-2-pyridone (3) by resolving a racemic mixture of the compounds (2) and (3). More specifically, disclosed is a method of obtaining the optically active nicotine derivatives (2) and (3) shown below, which comprises steps of binding (.+-.)-3-(1-methyl-2-pyrrolidinyl)-2-pyridone to a sugar derivative, resolving the obtained compound into two types of stereoisomers, and treating them under an acidic condition. ##STR1##

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