Optical resolution method of (.+-.)-3,4-dihydroxybutanoic acid

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

549313, C07B 5700, C07D30732

Patent

active

060692707

ABSTRACT:
An optical resolution method of (.+-.)-3,4-dihydroxybutanoic acid, by reacting (.+-.)-3,4-dihydroxybutanoic acid with an optically active primary amine or secondary amine. Also a method for producing optically active 3-hydroxy-.gamma.-butyrolactone, by reacting (.+-.)-3,4-dihydroxybutanoic acid with an optically active primary amine or secondary amine for optical resolution, and ring closing the resulting optically active 3,4-dihydroxybutanoic acid.

REFERENCES:
patent: 4845272 (1989-07-01), Nohira et al.
patent: 4904822 (1990-02-01), Nohira et al.
patent: 5191112 (1993-03-01), Nohira et al.
patent: 5321154 (1994-06-01), Nohira
patent: 5371282 (1994-12-01), Nohira et al.
patent: 5780649 (1998-07-01), Yuasa et al.
E.E. Kim, et al., J. Am. Chem. Soc., vol. 117, pp. 1181 & 1182, 1995, "Crystal Structure of HIV-1 Protease in Complex with VX-478, A Potent and Orally Bioavailable Inhibitor of the Enzyme" Feb. 1995.
J.W.E. Glattfeld, et al., J. Am. Chem. Soc., vol. 42, pp. 2314-2321, 1920, "The C.sub.4 -Saccharinic Acids. I. The Resolution of DL-2,3-Dioxybutyric Acid into the Optically-Active Components. The Derivatives of These Acids" Apr. 1920.
Optical Resolution Information Center, vol. 2, pp. 83 & 1123, "Optical Resolution Procedures for Chemical Compounds" Aug. 1977.
J.W.E. Glattfeld, "The C.sub.4- Saccharinic Acids. I. The resolution of Di-2,3-Diosybutyric Acid Into The Optically-Active Components. The Derivatives of these acids", Journal of the American Chemical Society, vol. 42, No. 11, pp. 2314-2321, Nov. 1920.
J.Jacques et al. "Enantiomers, Racemates and Resolution", Krieger Publishing Company, pp. 253-259 (1991) Month Unavailable.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Optical resolution method of (.+-.)-3,4-dihydroxybutanoic acid does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Optical resolution method of (.+-.)-3,4-dihydroxybutanoic acid, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Optical resolution method of (.+-.)-3,4-dihydroxybutanoic acid will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1911389

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.