Optical resolution method

Details Optical resolution method Optical resolution method

1994-08-19

1996-04-23

Cintins, Marianne M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562402, 568735, 560 56, C07D22706

Patent

active

055105203

ABSTRACT:
The present invention provides three optical resolution methods. The first aspect comprises the steps of adding an optically active bifunctional resolving reagent to a bifunctional compound to form a liquid material, precipitating crystals therefrom, and treating the crystals and the liquid material separately with an acidic material, a basic material, or a basic material and an acidic material, to obtain a pair of enantiomers of an optically active bifunctional compound. The second aspect comprises an optical resolution method by which one necessary enantiomer of a pair of enantiomers in an optically active bifunctional compound is exclusively obtained. The third aspect comprises a method for racemizing one unnecessary enantiomer of a pair of enantiomers in an optically active bifunctional compound which is formed by the optical resolution method of the present invention.

REFERENCES:
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Kawashima et al., Chemistry Letters, No. 12, Dec. 1990, pp. 2299-2300.
Kawashima et al., Chemistry Letters, No. 5, May 1991, pp. 763-766.
Toda et al., The Journal of Organic Chemistry, vol. 53, No. 15, 22nd Jul. 1988, pp. 3607-3609.
Toda et al., Tetrahedron Letters, vol. 29, No. 15, 1988, pp. 1807-1810.
Toda et al., Tetrahedron Letters, vol. 25, No. 43, 1984, pp. 4929-4932.
Tamai et al., Synthesis, No. 3, Mar. 1990, pp. 222-223.
Hutchins et al., The Journal of Organic Chemistry, vol. 45, No. 12, 6th Jun. 1980, pp. 2414-2418.
Muriel et al, Journal of the Chemical Society, 1955, pp. 1242-1251.

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