Optical resolution method

Organic compounds -- part of the class 532-570 series – Organic compounds – Carboxylic acids and salts thereof

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567402, 568735, 560 56, C07D22706

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active

053959620

ABSTRACT:
The present invention provides three optical resolution methods. The first aspect comprises the steps of adding an optically active bifunctional resolving reagent to a bifunctional compound to form a liquid material, precipitating crystals therefrom, and treating the crystals and the liquid material separately with an acidic material, a basic material, or a basic material and an acidic material, to obtain a pair of enantiomers of an optically active bifunctional compound. The second aspect comprises an optical resolution method by which one necessary enantiomer of a pair of enantiomers in an optically active bifunctional compound is exclusively obtained. The third aspect comprises a method for racemizing one unnecessary enantiomer of a pair of enantiomers in an optically active bifunctional compound which is formed by the optical resolution method of the present invention.

REFERENCES:
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Muriel et al., Journal of the Chemical Society, 1955, pp. 1242-1251.
Toda et al., "Efficient Optical Resolution of 2,2'-Dihydroxy-1,1'-binaphthyl and Related Compounds by Complex Formation with Novel Chiral Host Compounds Derived from Tartaric Acid" J. Org. Chem. 53, pp. 3607-3609, 1988.

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