Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or...
Reexamination Certificate
2005-08-16
2005-08-16
Witz, Jean C. (Department: 1651)
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
C250S306000
Reexamination Certificate
active
06929934
ABSTRACT:
The present invention pertains to an apparatus for imaging an object, comprising a probe via which an assay component may be delivered; a sensor to detect ion current; and means for controlling the position of the probe relative to the object in response to the ion current. Such apparatus can be used to image live cells, without affecting them, in solution, e.g., using light, wherein the distance between probe and cell is less than the wavelength of light.
REFERENCES:
patent: 4917462 (1990-04-01), Lewis et al.
patent: 4924091 (1990-05-01), Hansma et al.
patent: 5105305 (1992-04-01), Betzig et al.
patent: 5166520 (1992-11-01), Prater et al.
patent: 5254854 (1993-10-01), Betzig
patent: 5354985 (1994-10-01), Quate
patent: 5479024 (1995-12-01), Hillner et al.
patent: 5485536 (1996-01-01), Islam
patent: 5874726 (1999-02-01), Haydon
patent: 6621079 (2003-09-01), Shao et al.
patent: 09196936 (1997-07-01), None
patent: 09211010 (1997-08-01), None
patent: WO 98/37440 (1998-08-01), None
patent: WO 98/50791 (1998-11-01), None
patent: WO 00/63736 (2000-10-01), None
Lewis. A. et al. “Fountain Pen Nanochemistry: Atomic Force Control of Chrome Etching”Applied Physics Letters, Oct. 25, 1999. pp. 2689-2691, vol. 75, No. 17.
Korchev. Y, et al “Hybrid Scanning Ion Conductance and Scanning Near-Field Optical Microscopy for the Study of Living Cells”Biophysical Journal, May 2000, pp. 1-5, vol. 78.
Keller, T H “Scanning Near-Field Optical Microscopy in Reflection Mode Imaging in Liquid”Rev. Sci. Intrum., Mar. 1997, pp. 1448-1454, vol. 68. No. 3.
Korchev, Y E “Scanning Ion Conductance Microscopy of Living Cells”Biophysical Journal. Aug. 1997, pp. 653-658, Vol. 73.
Hansma. P.K. “The Scanning Ion-Conductance Microscope”Reports. Feb. 3, 1989, pp. 641-643, vol. 243.
Jandt, K.D. “Development and Perspectives of Scanning Probe Microscopy (SPM) on Organic Materials Systems”Materials Science and Engineering, 1998, pp. 221-295, vol. 21.
Tan, W. “Optical Measurements on the Nanometer Scale”Trends in Analytical Chemistry, 1998, pp. 501-513, vol. 17, Nos. 8 and 9.
Korchev, Y. E. et al. “Specialized Scanning Ion-Conductance Microscope for Imaging of Living Cells”Journal of Microscopy, 1997, pp. 17-23, vol. 188, Part 1.
Klenerman David
Korchev Yuri Evgenievich
Lab Max Joseph
Hanley Susan
Imperial College Innovations Ltd.
Saliwanchik Lloyd & Saliwanchik
Witz Jean C.
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