Optical measurement of tissue pH

Surgery – Truss – Pad

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

A61B 5000

Patent

active

058134034

ABSTRACT:
The invention provides an optical method and apparatus for determining the pH of a tissue. The method includes the step of first irradiating the tissue with optical radiation. The radiation may first pass through skin covering the tissue of interest, or may irradiate the tissue directly. Radiation reflected from the tissue is then collected to determine a reflection spectrum. pH is then determined by comparing this spectrum to a mathematical model relating optical properties to pH of the tissue.

REFERENCES:
patent: 4033330 (1977-07-01), Willis et al.
patent: 4041932 (1977-08-01), Fostick
patent: 5337745 (1994-08-01), Benaron
patent: 5355880 (1994-10-01), Thomas et al.
patent: 5435309 (1995-07-01), Thomas et al.
patent: 5441053 (1995-08-01), Lodder et al.
patent: 5494032 (1996-02-01), Robinson et al.
patent: 5522389 (1996-06-01), Fischer et al.
Benaron, "Optical Biopsy and Imaging Advance Medical Care", Laser Focus World, 79-87, Jan. 1994.
Benesch et al., "Equations for the Spectrophotometric Analysis of Hemoglobin Mixtures", Anal Biochem 55:245-248, 1973.
Drennen et al., "Near-Infrared Spectrometric Determination of Hydrogen Ion, Glucose, and Human Serum Albumin in a Simulated Biological Matrix", Spectroscopy, 6:28-34, 1991.
Dunn et al., "Experimental and Chemical Use of pH Monitoring of Free Tissue Transfers", Anals of Plastic Surgery, 30:1-7, 1993.
Hampson et al., "Near Infrared Monitoring of Human Skeletal Muscle Oxygenation During Forearm Ischemia", American Physiological Society, 2449-2453, 1988.
Parsons et al., "Dynamic Mechanisms of Cardiac Oxygenation During Brief Ischemia and Reperfusion", American Physiological Society, 1477-1485, 1990.
Reeves, "Influence of pH, Ionic Strength, and Physical State on the Near-Infrared Spectra of Model Compounds" J. of AOAC International, 77:814-820, 1994.
Robinson et al., "Noninvasive Glucose Monitoring in Diabetic Patients: A Preliminary Evaluation" Clinical Chemistry, 38:1618-1622, 1992.
Snell et al., "A Convenient Spectroscopic Method for the Estimation of Hemoglobin Concentrations in Cell-Free Solutions", J. Biochem & Biophys Methods 17:25-34, 1988.
Sobezynski, "Diode Arrays May Light Up Compact Spectrometers", Laser Focus World, 75-81, Mar. 1995.
Wait, "Fiber-Optic Sensors for Continuous Clinical Monitoring", Proceedings of the IEEE, 80:903-911, 1992.
Ward et al., "Post-Prandial Blood Glucose Determination by Quantitative Mid-Infrared Spectroscopy", Applied Spectroscopy, 46:959-965, 1992.
Vari et al., "Blood Perfusion and pH Monitoring in Organs Via Optical Biopsy", Am. Soc. for Lasers in Surgery and Medicine Supplement 7:3, Abstract 10, 1995 (Apr.).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Optical measurement of tissue pH does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Optical measurement of tissue pH, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Optical measurement of tissue pH will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-678203

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.