Optical isomers of 7-[3-(1,1-dialkylmethyl-1-amino-1-pyrrolidiny

Details Optical isomers of 7-[3-(1,1-dialkylmethyl-1-amino-1-pyrrolidiny Optical isomers of 7-[3-(1,1-dialkylmethyl-1-amino-1-pyrrolidiny

1993-10-05

1994-11-15

Dentz, Bernard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514312, 546123, 546156, A61K 31435, A61K 3147, C07D47104, C07D21556

Patent

active

053648617

ABSTRACT:
Optically pure isomers of 7-[3-(1,1-dialkylmethyl-1-amino)-1-pyrrolidinyl]quinolones and naphthyridones as therapeutically active and safe antibacterial agents are described, as well as pharmaceutical compositions thereof, and a method of treating bacterial infections therewith. Also described is a method of manufacture of the quinolones and naphthyridones as well as the starting materials, the optically pure pyrrolidine moieties for attachment at the 7-position.

REFERENCES:
patent: 4665079 (1987-05-01), Culbertson et al.
patent: 4780468 (1988-10-01), Bridges et al.
patent: 5098912 (1992-03-01), Hayakawa et al.

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