Optical isomers

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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546 18, A61K 31435, C07D41104

Patent

active

049818589

ABSTRACT:
The (+)-cis-, (-)-cis-, (+)-trans- and (-)-trans- forms of 2-methylspiro(1,3-oxathiolan-5,3')quinuclidine are prepared by optical resolution of each of the (.+-.)-cis- and (.+-.)-trans-isomers. These compounds find application in treating diseases of the central nervous system in mammals, especially diseases due to a deficiency in the central cholinergic system. Biological tests indicate that the (-)-cis-form, as well as the (.+-.)-cis-isomer, shows particular promise for treating senile dementia of Alzheimer's type.

REFERENCES:
patent: 4855290 (1989-08-01), Fisher et al.
Saunders et al., J. Med. Chem. 30: 969-975 (1987).
Watson et al., J. Pharm. Exp. Ther. 237: 411-418 (1986).
The Merck Index, 10th ed., Merck & Co., Inc. Rahway, N.J., (1983), Monograph No. 6328.

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