Optical imaging of induced signals in vivo under ambient...

Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation

Reexamination Certificate

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C424S009600

Reexamination Certificate

active

07668587

ABSTRACT:
A method for detecting and localizing a target tissue within the body in the presence of ambient light in which an optical contrast agent is administered and allowed to become functionally localized within a contrast-labeled target tissue to be diagnosed. A light source is optically coupled to a tissue region potentially containing the contrast-labeled target tissue. A gated light detector is optically coupled to the tissue region and arranged to detect light substantially enriched in target signal as compared to ambient light, where the target signal is light that has passed into the contrast-labeled tissue region and been modified by the contrast agent. A computer receives signals from the detector, and passes these signals to memory for accumulation and storage, and to then to image processing engine for determination of the localization and distribution of the contrast agent. The computer also provides an output signal based upon the localization and distribution of the contrast agent, allowing trace amounts of the target tissue to be detected, located, or imaged. A system for carrying out the method is also described.

REFERENCES:
patent: 4608990 (1986-09-01), Elings
patent: 5131398 (1992-07-01), Alfano et al.
patent: 5213105 (1993-05-01), Gratton et al.
patent: 5371368 (1994-12-01), Alfano et al.
patent: 5386827 (1995-02-01), Chance et al.
patent: 5391139 (1995-02-01), Edmundson
patent: 5601087 (1997-02-01), Gunderson et al.
patent: 5647368 (1997-07-01), Zeng et al.
patent: 5648269 (1997-07-01), Lakowicz et al.
patent: 5650135 (1997-07-01), Contag et al.
patent: 5672333 (1997-09-01), Rajagopalan et al.
patent: 5697373 (1997-12-01), Richards-Kortum et al.
patent: 5699798 (1997-12-01), Hochman et al.
patent: 5865754 (1999-02-01), Sevick-Muraca et al.
patent: 5874726 (1999-02-01), Haydon
patent: 5919140 (1999-07-01), Perelman et al.
patent: 5928627 (1999-07-01), Kiefer et al.
patent: 5936731 (1999-08-01), Cabib et al.
patent: 6091983 (2000-07-01), Alfano et al.
patent: 6256529 (2001-07-01), Holupka et al.
patent: 6649143 (2003-11-01), Contag et al.
patent: 6748259 (2004-06-01), Benaron et al.
patent: 6923951 (2005-08-01), Contag et al.
patent: 7255851 (2007-08-01), Contag et al.
patent: 2126717 (1984-03-01), None
patent: WO 93/13395 (1993-07-01), None
patent: WO 96/32892 (1996-10-01), None
patent: WO 97/36619 (1997-10-01), None
patent: WO 98/10698 (1998-03-01), None
patent: WO 98/48846 (1998-11-01), None
patent: WO 99/53832 (1999-10-01), None
Ballou, B., et al. “Tumor Labeling in Vivo Using Cyanine-Conjugated Monoclonal Antibodies”, Cancer Immunol. Immunother, (1995), vol. 41: pp. 257-263.
Hüber, M. et al. “Fluorescently Detectable Magnetic Resonance Imaging Agents” Bioconjugate Chem. 1998, vol. 9, pp. 242-249.
Lam, S. et al., “Detection of Early Lung Cancer Using Low Dose Photfrin II”, Chest, Feb. 1990, vol. 97 No. 2: pp. 333-337.
Sweeney, T.J. et al. “Visualizing the Kinetics of Tumor-Cell Clearance in Living Animals”, Proc Natl. Acad. Sci., Oct. 12, 1999, vol. 96 No. 21: pp. 12044-12049.
Weissleder, R. et al., “In Vivo Imaging of Tumor with Protease-Activated Near-Infrared Fluorescent Probes”, Nature Biotech, Apr. 1999, vol. 17: pp. 375-378.

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