Optical glucose sensor

Details Optical glucose sensor Optical glucose sensor

1994-07-18

1997-02-25

Sykes, Angela D.

Surgery

Truss

Pad

128637, 356 39, 422 8208, 436172, A61B 500, G02B 600

Patent

active

056051522

ABSTRACT:
An improved glucose sensor adapted for in vivo implantation includes one or more optical fiber optrodes mounted within a semipermeable probe housing designed for differential diffusion of glucose and oxygen. In a preferred form, an enzyme optrode comprises an optical fiber with an enzyme coating such as glucose oxidase for catalyzing glucose in the presence of oxygen (O.sub.2) to produce gluconic acid and hydrogen peroxide. An oxygen sensitive coating such as a fluorescent dye is provided on the enzyme optrode in close proximity with the enzymatic reaction, and also on a reference optrode at a position spaced substantially from the enzymatic reaction. Optical monitoring of the fluorescent activity of the optrode coatings provides an indication of oxygen depletion as a result of the enzymatic reaction, and thus also indicates glucose concentration level. The semipermeable housing is designed to ensure that the reaction proceeds with a stoichiometric excess of oxygen (O.sub.2).

REFERENCES:
patent: 3814081 (1974-06-01), Mori
patent: 3839154 (1974-10-01), Messing
patent: 3857771 (1974-12-01), Sternberg
patent: 3919051 (1975-11-01), Koch et al.
patent: 3992631 (1976-11-01), Harte
patent: 4056724 (1977-11-01), Harte
patent: 4231754 (1980-11-01), Vogelhut
patent: 4269938 (1981-05-01), Frank
patent: 4340669 (1982-07-01), Bauer
patent: 4353984 (1982-10-01), Yamada et al.
patent: 4476870 (1984-10-01), Peterson et al.
patent: 4517291 (1985-05-01), Seago
patent: 4548907 (1985-10-01), Seitz et al.
patent: 4557900 (1985-12-01), Heitzmann
patent: 4560248 (1985-12-01), Cramp et al.
patent: 4606351 (1986-08-01), Lubbers
patent: 4680268 (1987-07-01), Clark, Jr.
patent: 4721677 (1988-01-01), Clark, Jr.
patent: 4974929 (1990-12-01), Curry
patent: 4981779 (1991-01-01), Wagner
patent: 5001054 (1991-03-01), Wagner
patent: 5409666 (1995-04-01), Nagel et al.
patent: 5462880 (1995-10-01), Kane et al.
1985 American Chemical Society--Two-Dimensional Enzyme Elect. Reprint from Analytical Chem.
Diabetes Care. vol. 5 No. 3 May-Jun. 1982.
David A. Gough, Ph.D.--The UCSD Implantable Glucose and Oxygen Sensor Tech. Feb. 3, 1986.
In Vitro Stability of an Oxygen Sensor--Analytical Chemistry, 1987.
Optical Glucose Sensor Based on Reversible Competitive Binding--Symposium on Biosensors--1984.
IEEE Transactions on Biomedical Engineering vol. 35 No. 7 Jul. 1988.

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