Optical determination of glucose utilizing boronic acid adducts

Details Optical determination of glucose utilizing boronic acid adducts Optical determination of glucose utilizing boronic acid adducts

2011-06-28

2011-06-28

Aulakh, Charanjit S (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S257000

Reexamination Certificate

active

07968714

ABSTRACT:
The present invention concerns an improved optical method and optical sensing device for determining the levels of polyhydroxyl-substituted organic molecules in vitro and/or in vivo in aqueous media. The range of detection is between about 400 and 800 nm. In particular, a sensory devise is implemented in a mammal to determine sugar levels. Specifically, a dye is combined with a conjugated nitrogen-containing heterocyclic aromatic boronic acid-substituted bis-onium compound in the presence of a sugar, such as fructose or glucose. The viologens are preferred as the aromatic conjugated nitrogen-containing boronic acid substituted compounds. The method is useful to determine sugar levels in a human being.

REFERENCES:
patent: 6627177 (2003-09-01), Singaram et al.
patent: 6653141 (2003-11-01), Singaram et al.

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