Optical detection system for capillary separation columns

Details Optical detection system for capillary separation columns Optical detection system for capillary separation columns

1991-08-13

1993-08-10

McGraw, Vincent P.

Optics: measuring and testing

For light transmission or absorption

Of fluent material

356 72, 356 73, 356244, 356440, 359737, G01N 2101, G01N 2159, G01N 2164

Patent

active

052354091

ABSTRACT:
On-column optical detection apparatus and method for use with capillary separation columns are shown. The apparatus and method minimize the adverse effects of light scattered from the walls of the column, thereby improving detection sensitivity and providing greater dynamic range. Light from a conventional source is focussed onto a column. Spatial filter means are positioned in front of the column to prevent at least some light from striking the column wall. Another spatial filter is positioned in front of a light collecting means which gathers light emanating from the column. In a specific embodiment, a unique monolens design is shown comprising collecting and focussing lens formed as an integral unit with a bore for a capillary column.

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