Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Patent
1997-10-06
1999-11-16
O'Connor, Cary
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
600476, A61B 600
Patent
active
059873515
ABSTRACT:
For in vivo examination using a spectrophotometer that generates optical radiation and characterizes biological tissue by detecting photons that have migrated in the tissue, an array of optical fibers that transmit radiation between the spectrophotometer and biological tissue, the fibers including distal ends freely protruding from a support in the manner of bristles from a hairbrush, forming an array of optical ports to couple photons to a contiguous tissue region or to collect photons from the tissue region, the optical fibers including proximal ends arranged to optically couple the radiation with the spectrophotometer. Also shown are: fibers sized and distributed to penetrate freely extending hair on the subject's head to make optical contact over an array of points with the scalp or skin; the array of fibers constructed as a handheld probe moved and placed against the head; optical matching material coupling between the fibers and the biological tissue region; and an irradiation array with the proximal fiber ends coupled to a light source, e.g. for brain tissue examination. Also shown are fibers as a detection array, e.g. for brain tissue examination or for imaging of the brain or for use in a magnet used for magnetic resonance imaging. The spectrophotometer is shown as a continuous wave spectrophotometer, phase modulation spectrophotometer, time resolved spectrophotometer and a phased array spectrophotometer.
REFERENCES:
patent: 3068742 (1962-12-01), Hicks, Jr. et al.
patent: 3412729 (1968-11-01), Smith, Jr.
patent: 3461856 (1969-08-01), Polanyi
patent: 3638640 (1972-02-01), Shaw
patent: 3709612 (1973-01-01), Clemens
patent: 3866599 (1975-02-01), Johnson
patent: 3994585 (1976-11-01), Frey
patent: 3998550 (1976-12-01), Konishi et al.
patent: 4086915 (1978-05-01), Kofsky et al.
patent: 4119406 (1978-10-01), Clemens
patent: 4138727 (1979-02-01), Mantz
patent: 4162405 (1979-07-01), Chance et al.
patent: 4167331 (1979-09-01), Nielsen
patent: 4223680 (1980-09-01), Jobsis
patent: 4281645 (1981-08-01), Jobsis
patent: 4321930 (1982-03-01), Jobsis et al.
patent: 4380240 (1983-04-01), Jobsis et al.
patent: 4416285 (1983-11-01), Shaw et al.
patent: 4510938 (1985-04-01), Jobsis et al.
patent: 4612938 (1986-09-01), Dietrich et al.
patent: 4800885 (1989-01-01), Johnson
patent: 4805623 (1989-02-01), Jobsis
patent: 4824242 (1989-04-01), Frick et al.
patent: 4846183 (1989-07-01), Martin
patent: 4908762 (1990-03-01), Suzuki et al.
patent: 4972331 (1990-11-01), Chance
patent: 5088493 (1992-02-01), Giannini et al.
patent: 5090415 (1992-02-01), Yamashita et al.
patent: 5106387 (1992-04-01), Kittrell et al.
patent: 5119815 (1992-06-01), Chance
patent: 5187672 (1993-02-01), Chance et al.
patent: 5190039 (1993-03-01), Takeuchi et al.
patent: 5300097 (1994-04-01), Lerner et al.
patent: 5358503 (1994-10-01), Bertwell et al.
patent: 5408093 (1995-04-01), Ito et al.
patent: 5551422 (1996-09-01), Simonsen et al.
patent: 5625458 (1997-04-01), Alfano et al.
patent: 5655530 (1997-08-01), Messerschmidt
patent: 5706821 (1998-01-01), Matcher et al.
Chance et al., "Photon Migration in Muscle and Brain," Photon Migration in Tissues, Plenum Press, pp. 121-135, 1989, Chance, B., ed.
Cui et al., "Experimental Study of Migration Depth for the Photons Measured at Sample Surface," SPIE, 1431:180-191, 1991.
Greenfeld, "A Tissue Model For Investigating Photon Migration in Trans-Cranial Infrared Imaging," Photon Migration in Tissues, Plenum Press, B. Chance, ed., pp. 147-168, 1989.
Sevick et al., "Analysis of absorption, scattering, and hemoglobin saturation using phase modulation spectroscopy," SPIE, 1431:264-275, 1991.
Sevick et al., "Photon migration in a model of the head measured using time-and frequency-domain techniques: potentials of spectroscopy and imaging," SPIE, 1431:84-96, 1991.
Weng et al., "Measurement of Biological Tissue Metabolism Using Phase Modulation Spectroscopy Technology," SPIE, 1431:161-171, 1991.
Non-Invasive Technology Inc.
O'Connor Cary
Winakur Eric F.
LandOfFree
Optical coupler for in vivo examination of biological tissue does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Optical coupler for in vivo examination of biological tissue, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Optical coupler for in vivo examination of biological tissue will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1336592