Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving blood clotting factor
Patent
1996-01-29
1998-02-10
Gitomer, Ralph
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving blood clotting factor
427212, C12Q 156, B05D 700
Patent
active
057167966
ABSTRACT:
A method for optically measuring the functional capacity of blood platelets and the blood clotting system. The method consists of detection of platelet aggregation in a platelet-containing specimen fluid, whereby the specimen fluid is contacted with a platelet agonist and disclosure reagent. A mechanical specimen-handling apparatus with one or more optical end-point detectors which is preferred for use with the method of the invention is also described. The apparatus incubates a small quantity of diluted whole blood with added solid or liquid reagents at body temperature, and mixes the blood via rocking and rotational motions so as to expose the blood uniformly to the reagents. The optical end-point detectors then measure the activity of platelets within the blood specimen, clotting time, and the clotting cascade. Several intermediate measurements are also available.
REFERENCES:
patent: 3944687 (1976-03-01), Morisaki
patent: 5091304 (1992-02-01), La Duca
Wintrobe M., Clinical Hematology 7th Ed. 1974 Lea & Febiger, Phila.
Bull Brian S.
Korpman Ralph A.
Gitomer Ralph
Medical Devices Corporation
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