Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1989-09-22
1992-06-02
Kepplinger, Esther L.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 731, 435 732, 435 78, 435805, 435808, 436164, 436171, 436518, 436531, 436805, 356305, 356317, 356318, 2504611, 2504612, G01N 3353, G01N 2141, G01N 33543
Patent
active
051186080
ABSTRACT:
An assay technique for qualitative and quantitative detection of a chemical, biochemical or biological detection of a chemical, biochemical or biological species in sample. The technique comprises: (a) coating at least a predetermined part of a pre-formed surface on a substrate with a thin film of a material capable of binding the species to be assayed, the pre-formed surface being optically active with respect to radiation at least over a predetermined band of wavelengths; (b) contacting the coated surface with sample; and (c) observing the optical properties of said pre-formed surface in order to determine a qualitative and quantitative change in optical properties as a result of the binding of the species onto said thin film of material. The optical properties as a result of the pre-formed surface may be observed before and after step (b) in order to determine any change in optical properties, or they may be monitored during step (b). The pre-formed surface is preferably a grating. An article for use in the above technique is also disclosed, and comprises a substrate carrying said pre-formed surface which in turn is coated with the receptive material for the species to be assayed.
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Fisher John H.
Layton Derek G.
Pettigrew Robert M.
Petty-Saphon Satham
Smith Alan M.
Ares-Serono N.V.
Kepplinger Esther L.
Scheiner Toni R.
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