Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is inorganic
Patent
1986-04-04
1989-10-31
Hill, Jr., Robert J.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is inorganic
350 9615, 350 9619, 350 9634, 422 57, 422 58, 422 68, 422 69, 435808, 436164, 436805, 436807, G01N 2177, G01N 33553
Patent
active
048777471
ABSTRACT:
An optical assay apparatus of the type comprising an optic waveguide and a coating sensitized to a specific assay species. The light signal response of the apparatus is enhanced by coupling a resonant metallic medium to the waveguide and to the sensitized coating. To this end, a metal coated transparent buffer layer may be interposed between the waveguide and the sensitized coating. Alternatively, a metallized optically matched grating can be used in place of the buffer layer or the metallic medium can be of particulate form, with each particle having a sensitized coating.
In using the optical assay apparatus, the sensitized coating is exposed to a fluid assay sample. A light beam is directed onto the sensitized coating and reflected onto a detector. The detected light is monitored for any change indicating the presence of the specific assay species in the fluid sample.
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patent: 4521522 (1985-06-01), Lundstrom et al.
Sutherland, R. M. et al., "Detection of Antibody-Antigen Reactions at a Glass-Liquid Interface as a Novel Optical Immunoassay Concept", Proceedings of 2nd Optical Fibre Conference, (Stuttgart 1984), p. 75.
Hill Jr. Robert J.
Plessey Overseas Limited
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