Optical activity detector for use with optically active compound

Details Optical activity detector for use with optically active compound Optical activity detector for use with optically active compound

1997-10-31

1998-10-13

Rosenberger, Richard A.

Optics: measuring and testing

By polarized light examination

With polariscopes

G01N 2121

Patent

active

058220674

ABSTRACT:
An improved optical rotation detector for detecting optically active molecular compounds in a sample solution using: a laser diode with the beam passing through an optical fiber or lens to improve its quality, a reference oscillator at frequency f, a first polarizer, a specially constructed flow cell to minimize mechanical birefringence and leaking in the cell's optical windows, a second polarizer, and an improved detection scheme. The detection scheme includes a first and second photodetector for sensing first and second signals, where the first signal is light passed through the second polarizer and the second signal is light reflected off the second polarizer. A compensator circuit low pass filters the signals, inverts one signal and sums it with the other, and then notch filters off the undesired components to produce a compensated signal. The compensated signal then drives a lock-in amplifier which is driven by the reference oscillator to sense the amplitude modulated f frequency signal. This compensated signal indicates the optical activity of the sample, yet is immune to laser power fluctuations.

REFERENCES:
patent: 2753479 (1956-07-01), Aughey et al.
patent: 3510226 (1970-05-01), Cary
patent: 4019372 (1977-04-01), Parkell et al.
patent: 5408322 (1995-04-01), Hsu et al.

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