Opioid peptides derived from wheat proteins

Details Opioid peptides derived from wheat proteins Opioid peptides derived from wheat proteins

1991-12-02

1993-12-07

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 17, 530329, 530330, A61K 3700, C07K 500

Patent

active

052683605

ABSTRACT:
Disclosed are opioid peptides recovered from hydrolysates of wheat proteins with an acid protease and further a neutral or alkaline protease. Of those peptides, the structure of four opioid peptides was identified by the amino acid sequence of Gly-Tyr-Tyr-Pro (SEQ ID NO:1), Gly-Tyr-Tyr-Pro-Thr (SEQ ID NO:2), Gly-Tyr-Tyr-Pro-Thr-Ser (SEQ ID NO:3) or Tyr-Pro-Ile-Ser-Leu (SEQ ID NO:4). They are useful as a medicine such as narcotic, analgesic or the like.

REFERENCES:
Journal of Biological Chemistry, vol. 254, No. 7, Apr. 10, 1979, pp. 2446-2449, C. Zioudrou, et al. "Opioid Peptides Derived from Food Proteins".
Peptides, vol. 5, Ankho International Inc. USA, 1984, pp. 1139-1147, F. R. Huebner, et al., "Demonstration of High Opioid-Like Activity in Isolated Peptides from Wheat Gluten Hydrolysates".
Gastroenterology, vol. 84, No. 6, American Gastroenterological Association, 1983, pp. 1517-1523, J. E. Morley, et al., "Effect of Exorphins on Gastrointestinal Function, Hormonal Release, and Appetite".
Journal of Medicinal Chemistry, vol. 21, No. 11, American Chemical Society, 1978, pp. 1110-1115, P. W. Schiller, et al. "Synthesis, Opiate Receptor Affinity, and Conformational Parameters of [4-Tryptophan]Enkephalin Analogues".

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