Opioid peptide inhibitors

Details Opioid peptide inhibitors Opioid peptide inhibitors

1993-05-19

1994-11-22

Hill, Jr., Robert J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

6 to 7 amino acid residues in defined sequence

530328, A61K 3702, C07K 500, C07K 700, C07K 1500

Patent

active

053670531

ABSTRACT:
This invention provides novel peptides having the ability to inhibit binding of the mu specific ligand .sup.3 H-[D-Ala.sup.2,MePhe.sup.4,Gly-ol.sup.5 ]enkephalin ("DAGO") to the opioid receptors in crude rat brain homogenate.

REFERENCES:
patent: 4833092 (1989-05-01), Geysen
patent: 5010175 (1991-04-01), Rutter et al.
patent: 5194392 (1993-03-01), Geysen
Houghten et al., "Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery" Nature 354:84-86 (1991).
Houghten et al., "The Use of Synthetic Peptide Combinatorial Libraries for the Identification of Bioactive Peptides" Biotechniques 13:412-421 (1992).
Pinilla et al., "Rapid Identification of High Affinity Peptide Ligands Using Positional Scanning Synthetic Peptide Combinatorial Libraries" Biotechniques 13:901-905 (1992).
Dooley and Houghten, "The Use of Positional Scanning Synthetic Peptide Combinatorial Libraries for the Rapid Determination of Opioid Receptor Ligands" Life Sciences 52:1509-1517 (1993).
Simon et al., "Peptoids: a Modular Approach to Drug Discovery" PNAS 89:9367-9371 (1992).

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