Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-01-21
1993-07-06
Tsang, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 35, A61K 3144, C07D49112
Patent
active
052254178
ABSTRACT:
The present invention provides substituted dibenzoxazepine compounds of Formula I: ##STR1## which are opioid agonists which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
REFERENCES:
patent: 4816586 (1989-03-01), Portoghese
Portoghese et al. J. Med. Chem., Design of Peptidomimetic Delta Opioid Receptor etc. 33 1714-1720, Jan. 1990.
Portoghese et al., J. Med. Chem., Application of the Message-Address Concept in etc. 31, No. 2 281-282 Jan. 1988.
Dappen Michael S.
Pitzele Barnett S.
Rafferty Michael F.
G. D. Searle & Co.
Hastreiter Roberta L.
Matukaitis Paul D.
Tsang Cecilia
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