Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1994-05-16
1995-07-25
Tsang, Cecilia
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 35, A61K 3144, C07D49112
Patent
active
054362490
ABSTRACT:
The present invention provides novel substituted opioid analgesic compounds of Formula I: ##STR1## which are opioid agonists, and which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
REFERENCES:
patent: 4816586 (1989-03-01), Portoghese
patent: 5225417 (1993-07-01), Dappen et al.
"Design of Peptidomimetic Delta Opiod Receptor Antagonists Using the Message Address Concept," J. Med. Chem. 33, pp. 1714-1720, Jan., 1990, U.S.A.
"Application of the Message Address Concept in the Design of Highly Potent and Selective Non-Peptide S Opiod Receptor Antagonists," J. Med. Chem. 31, No. 2, pp. 281-282, Jan., 1988, U.S.A.
Dappen Michael S.
Pitzele Barnett S.
Rafferty Michael F.
G. D. Searle & Co.
Hastreiter Roberta L.
Tsang Cecilia
Williams Roger A.
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