Opioid agonist/antagonist combinations

Details Opioid agonist/antagonist combinations Opioid agonist/antagonist combinations

2008-09-02

2008-09-02

Tran, S. (Department: 1618)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C424S451000, C424S457000, C424S458000, C424S464000, C424S468000, C424S469000

Reexamination Certificate

active

11645401

ABSTRACT:
The invention is directed in part to oral dosage forms comprising a combination of an orally analgesically effective amount of an opioid agonist and an orally active opioid antagonist, the opioid antagonist being included in a ratio to the opioid agonist to provide a combination product which is analgesically effective when the combination is administered orally, but which is aversive in a physically dependent subject. Preferably, the amount of opioid antagonist included in the combination product provides at least a mildly negative, “aversive” experience in physically dependent addicts (e.g., precipitated abstinence syndrome).

REFERENCES:
patent: 2770569 (1956-11-01), Fromherz et al.
patent: 3133132 (1964-05-01), Loeb et al.
patent: 3173876 (1965-03-01), Zobrist
patent: 3173877 (1965-03-01), Jackson et al.
patent: 3276586 (1966-10-01), Rosaen
patent: 3332950 (1967-07-01), Blumberg et al.
patent: 3493657 (1970-02-01), Lewenstein et al.
patent: 3541005 (1970-11-01), Strathmann et al.
patent: 3541006 (1970-11-01), Bixler et al.
patent: 3676557 (1972-07-01), Lachman et al.
patent: 3773955 (1973-11-01), Pachter et al.
patent: 3845770 (1974-11-01), Theeuwes et al.
patent: 3879555 (1975-04-01), Pachter et al.
patent: 3916889 (1975-11-01), Russell
patent: 3965256 (1976-06-01), Leslie
patent: 3966940 (1976-06-01), Pachter et al.
patent: 4063064 (1977-12-01), Saunders et al.
patent: 4088864 (1978-05-01), Theeuwes et al.
patent: 4160020 (1979-07-01), Ayer et al.
patent: 4176186 (1979-11-01), Goldberg
patent: 4200098 (1980-04-01), Ayer et al.
patent: 4237140 (1980-12-01), Dudzinski
patent: 4285987 (1981-08-01), Ayer et al.
patent: 4293539 (1981-10-01), Ludwig et al.
patent: 4366310 (1982-12-01), Leslie
patent: 4401672 (1983-08-01), Portoghese et al.
patent: 4443428 (1984-04-01), Oshlack et al.
patent: 4451470 (1984-05-01), Ganti
patent: 4457933 (1984-07-01), Gordon et al.
patent: 4464378 (1984-08-01), Hussain et al.
patent: 4573995 (1986-03-01), Chen et al.
patent: 4582835 (1986-04-01), Lewis et al.
patent: 4608376 (1986-08-01), Pasternak
patent: 4661492 (1987-04-01), Lewis et al.
patent: 4719215 (1988-01-01), Goldberg
patent: 4722928 (1988-02-01), Boswell et al.
patent: 4730048 (1988-03-01), Portoghese et al.
patent: 4760069 (1988-07-01), Rzeszotarski et al.
patent: 4769372 (1988-09-01), Kreek et al.
patent: 4785000 (1988-11-01), Kreek et al.
patent: 4803208 (1989-02-01), Pasternak
patent: 4806341 (1989-02-01), Chien et al.
patent: 4806543 (1989-02-01), Choi
patent: 4806558 (1989-02-01), Wuest et al.
patent: 4828836 (1989-05-01), Elger et al.
patent: 4834965 (1989-05-01), Martani et al.
patent: 4834984 (1989-05-01), Goldie et al.
patent: 4834985 (1989-05-01), Elger et al.
patent: 4844907 (1989-07-01), Elger et al.
patent: 4844909 (1989-07-01), Goldie et al.
patent: 4844910 (1989-07-01), Leslie et al.
patent: 4861598 (1989-08-01), Oshlack
patent: 4861781 (1989-08-01), Goldberg
patent: 4867985 (1989-09-01), Heafield et al.
patent: 4873076 (1989-10-01), Fishman et al.
patent: 4882335 (1989-11-01), Sinclair
patent: 4889860 (1989-12-01), Rzeszotarski et al.
patent: 4935428 (1990-06-01), Lewis
patent: 4940587 (1990-07-01), Jenkins et al.
patent: 4957681 (1990-09-01), Klimesch et al.
patent: 4970075 (1990-11-01), Oshlak
patent: 4987136 (1991-01-01), Kreek et al.
patent: 4990341 (1991-02-01), Goldie et al.
patent: 5071646 (1991-12-01), Malkowska et al.
patent: 5075341 (1991-12-01), Mendelson et al.
patent: 5086058 (1992-02-01), Sinclair et al.
patent: 5091189 (1992-02-01), Heafield et al.
patent: 5096715 (1992-03-01), Sinclair
patent: 5102887 (1992-04-01), Goldberg
patent: 5130311 (1992-07-01), Guillaumet et al.
patent: 5149538 (1992-09-01), Granger et al.
patent: 5215758 (1993-06-01), Krishnamurthy
patent: 5225440 (1993-07-01), London et al.
patent: 5226331 (1993-07-01), Thompson et al.
patent: 5236714 (1993-08-01), Lee et al.
patent: 5256669 (1993-10-01), Askanazi et al.
patent: 5266331 (1993-11-01), Oshlak et al.
patent: 5273760 (1993-12-01), Oshlak et al.
patent: 5286493 (1994-02-01), Oshlak et al.
patent: 5316759 (1994-05-01), Rose et al.
patent: 5317022 (1994-05-01), Borsodi et al.
patent: 5321012 (1994-06-01), Mayer et al.
patent: 5324351 (1994-06-01), Oshlak et al.
patent: 5336691 (1994-08-01), Raffa et al.
patent: 5352680 (1994-10-01), Portoghese et al.
patent: 5352683 (1994-10-01), Mayer et al.
patent: 5356467 (1994-10-01), Oshlak et al.
patent: 5356900 (1994-10-01), Bihari et al.
patent: 5376662 (1994-12-01), Ockert
patent: 5409944 (1995-04-01), Black et al.
patent: 5411745 (1995-05-01), Oshlack et al.
patent: 5426112 (1995-06-01), Zagon et al.
patent: 5436265 (1995-07-01), Black et al.
patent: 5457208 (1995-10-01), Portoghese et al.
patent: 5460826 (1995-10-01), Merrill et al.
patent: 5472712 (1995-12-01), Oshlack et al.
patent: 5472943 (1995-12-01), Crain et al.
patent: 5474995 (1995-12-01), Ducharme et al.
patent: 5478577 (1995-12-01), Sackler et al.
patent: 5486362 (1996-01-01), Kitchell et al.
patent: 5500227 (1996-03-01), Oshlack et al.
patent: 5502058 (1996-03-01), Mayer et al.
patent: 5508042 (1996-04-01), Oshlack et al.
patent: 5508043 (1996-04-01), Krishnamurthy
patent: 5510368 (1996-04-01), Lau et al.
patent: 5512578 (1996-04-01), Crain et al.
patent: 5514680 (1996-05-01), Weber et al.
patent: 5521213 (1996-05-01), Prasit et al.
patent: 5534492 (1996-07-01), Aston et al.
patent: 5536752 (1996-07-01), Ducharme et al.
patent: 5549912 (1996-08-01), Oshlack et al.
patent: 5550142 (1996-08-01), Ducharme et al.
patent: 5552422 (1996-09-01), Gauthier et al.
patent: 5556838 (1996-09-01), Mayer et al.
patent: 5574052 (1996-11-01), Rose et al.
patent: 5578725 (1996-11-01), Portoghese et al.
patent: 5580876 (1996-12-01), Crain et al.
patent: 5585348 (1996-12-01), Crain et al.
patent: 5591452 (1997-01-01), Miller et al.
patent: 5593994 (1997-01-01), Batt et al.
patent: 5601845 (1997-02-01), Buxton et al.
patent: 5604253 (1997-02-01), Lau et al.
patent: 5604260 (1997-02-01), Guay et al.
patent: 5616601 (1997-04-01), Khanna et al.
patent: 5622722 (1997-04-01), Knott et al.
patent: 5624932 (1997-04-01), Qin et al.
patent: 5633259 (1997-05-01), Qin et al.
patent: 5639476 (1997-06-01), Oshlack et al.
patent: 5639780 (1997-06-01), Lau et al.
patent: 5656295 (1997-08-01), Oshalck et al.
patent: 5670172 (1997-09-01), Buxton et al.
patent: 5672360 (1997-09-01), Sackler et al.
patent: 5681585 (1997-10-01), Oshlack et al.
patent: 5763452 (1998-06-01), Miller et al.
patent: 5767125 (1998-06-01), Crain et al.
patent: 5780479 (1998-07-01), Kim
patent: 5811126 (1998-09-01), Krishnamurthy
patent: 5834477 (1998-11-01), Mioduszewski
patent: 5843480 (1998-12-01), Miller et al.
patent: 5849240 (1998-12-01), Miller et al.
patent: 5858017 (1999-01-01), Demopulos et al.
patent: 5860950 (1999-01-01), Demopulos et al.
patent: 5866164 (1999-02-01), Kuczynski et al.
patent: 5869097 (1999-02-01), Wong et al.
patent: 5879705 (1999-03-01), Heafield et al.
patent: 5880132 (1999-03-01), Hill
patent: 5891471 (1999-04-01), Miller et al.
patent: 5908848 (1999-06-01), Miller et al.
patent: 5942241 (1999-08-01), Chasin et al.
patent: 5958452 (1999-09-01), Oshlack et al.
patent: 5958459 (1999-09-01), Chasin et al.
patent: 5965161 (1999-10-01), Oshlack et al.
patent: 5965163 (1999-10-01), Miller et al.
patent: 5968547 (1999-10-01), Reder et al.
patent: 5968551 (1999-10-01), Oshlack et al.
patent: 5972954 (1999-10-01), Foss
patent: 5998434 (1999-12-01), Mitch et al.
patent: 6024982 (2000-02-01), Oshlack et al.
patent: 6068855 (2000-05-01), Leslie et al.
patent: 6077532 (2000-06-01), Malkowska et al.
patent: 6077533 (2000-06-01), Oshlack et al.
patent: 6096756 (2000-08-01), Crain et al.
patent: 6103258 (2000-08-01), Simon
patent: 6103261 (2000-08-01), Chasin et al.
patent: 6143322 (2000-11-01), Sackler et al.
patent: 6143328 (2000-11-01), Heafield et al.
patent: 6162467 (2000-12-01), Miller et al.
patent: 6194382 (2001-02-01), Crain et al.
patent: 6210714 (2001-04-01), Oshlack et al.
patent: 6228863 (2001-05-01), Palermo et al.
patent: 6254887 (2001-07-01), Miller et al.
patent: 6261599 (2001-07-01), Oshlack e

Affiliated with

Also associated with

Rating

Opioid agonist/antagonist combinations does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Opioid agonist/antagonist combinations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Opioid agonist/antagonist combinations will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3954337